c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation.

Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle regeneration and maintenance. SCs function is critically dependent on two families of transcription factors: the paired box (Pax) involved in specification and maintenance and the Muscle Regulatory Factors (MRFs), which orchestrate myogenic commitment and differentiation. In turn, signaling events triggered by extrinsic and intrinsic stimuli control their function via post-translational modifications, including ubiquitination and phosphorylation.

USP7-dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors.

Satellite cells (SCs) are myogenic progenitors responsible for skeletal muscle regeneration and maintenance. Upon activation, SCs enter a phase of robust proliferation followed by terminal differentiation. Underlying this myogenic progression, the sequential expression of muscle regulatory transcription factors (MRFs) and the downregulation of transcription factor paired box gene 7 (Pax7) are key steps regulating SC fate.

[Tension pneumothorax in post-anesthetic care unit: case report.].

Background And Objectives: The incidence of pneumothorax after penetrating chest trauma is 100%. Tension pneumothorax, a high mortality rate condition, may be triggered, among other causes, by pulmonary injury not previously identified, and may also be associated to mechanical ventilation. This report presents a case of tension pneumothorax diagnosed in the Post-Anesthetic Care Unit (PACU).