Wound Characteristics Among Patients Exposed to Xylazine.

Importance: The alpha-2 agonist xylazine is increasingly detected as an adulterant in illicitly manufactured fentanyl. There is concern that xylazine may be responsible for an emerging pattern of necrotizing wounds among people who use drugs, but the clinical features of wounds associated with xylazine remain poorly characterized.

Objective: To systematically characterize the location, wound bed surface, and chronicity of wounds among persons with confirmed xylazine exposure.

Spectroscopic Characterization of the First and Second Excited States of the HOSO Radical.

The spectroscopic properties of the ground and first two excited states of the HOSO radical are investigated using the internally contracted multireference configuration interaction method, including the Davidson correction (MRCI+Q) and explicit treatment of the electron correlation (MRCI-F12). The vertical and adiabatic excitation energies are also determined. The results reveal that both the 1 A and 2 A electronic states contain minima in their potential energy surfaces.

Photochemistry from low-lying states of HOSO.

Using configuration interaction ab initio methods, the evolution of the lowest electronic states of singlet and triplet spin multiplicities of HOSO along the stretching and bending coordinates of is investigated. Equilibrium geometries, rotational constants, and harmonic vibrational frequencies of the lowest electronic states are calculated, i.e.