Publications by authors named "Natasa Kacanski"
Introduction: Childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) can be traced back to birth using leukemic clone-specific immunoglobulin heavy chain (IGH) rearrangements, implying prenatal origin of this disease.
Methods: We retrospectively analyzed neonatal blood spots (Guthrie cards) of 24 patients with childhood BCP-ALL aged 1-9.6 years (median 3.
Introduction: A family of a child with cancer needs continuous help and support from medical and other professionals, relatives, friends and community at the moment of making diagnosis and during the treatment. The goal of this study was to find out the most frequent sources of individual or community based psychological support, reported by parents of children suffering from malignant diseases. We focused on the help received at the moment of making diagnosis and within the first and second year of treatment.
View Article and Find Full Text PDFIntroduction: L-asparaginase (L-ASP) is one of the most effective medications for the treatment of acute lymphoblastic leukaemia (ALL) in children, and allergic reactions to the therapy are considered the most significant side effects.
Objective: The aim of this study was to determine the prevalence and type of allergic reactions, as well as to identify potential risk factors for the development of allergic reactions during L-ASP therapy in children with ALL.
Methods: The study encompassed 70 patients under 18 years of age, who were treated at the Institute for Child and Youth Healthcare of Vojvodina, Novi Sad in the period January 2000 - June 2009.
Article Synopsis
- Biphenotypic acute leukaemia features blasts that express both myeloid and either B- or T-lymphoid antigens, making it a rare and complex condition.
- Two pediatric cases illustrate the challenges in treating this leukaemia type: one patient had Philadelphia chromosome positivity and underwent intensive therapy but ultimately died from complications, while the other did not achieve remission despite treatment.
- The diagnosis relies heavily on immunophenotyping, and treatment must be tailored based on the individual patient's immunophenotype and genetic profile, emphasizing the need for more intensive and personalized approaches.