Publications by authors named "Natan Gorelik"
Article Synopsis
- Hematopoietic stem cell transplantation (HSCT) is the main treatment for infantile malignant osteopetrosis (IMO), but it can lead to serious side effects.
- A study analyzed 38 IMO patients who underwent HSCT, comparing the use of fludarabine-based conditioning regimens to other types.
- Results showed that fludarabine significantly improved overall survival (96% vs. 58%) and resulted in fewer complications, indicating it is a safer and more effective option for these patients.
Background: Treosulfan (treo) is an alkylating agent with a low acute toxicity profile that is increasingly used in hematopoietic stem cell transplantation, predominantly in non-malignant diseases. Treosulfan is usually combined with additional agents, but there is scant evidence to allow comparison between different conditioning protocols using treosulfan. We present the experience of three pediatric transplantation centers in Israel using different treosulfan-based conditioning regimens.
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