Publications by authors named "Natalya N Shusharina"
J Biomater Sci Polym Ed
August 2020
Article Synopsis
- The study focuses on developing biodegradable polymer coatings for stents using poly(lactic-co-glycolic acid) (PLGA), which can release large molecules like prourokinase over time.
- The coatings exhibit significant elasticity and tensile strength, degrade slowly in isotonic solutions (0.05%-1.0% per day), and maintain around 90% enzymatic activity of prourokinase during release.
- Testing in animals showed no short-term toxicity or complications post-surgery, with minimal traces of PLGA found after 60 days, indicating the coatings are safe and effective for medical use.
