Publications by authors named "Natalya Klimova"
Article Synopsis
- The study investigates how gene expressions linked to age-related diseases (ARDs) vary among different genders, ages, and disease types to improve personalized medicine approaches.
- Researchers sequenced the transcriptome of two types of rats—tame and aggressive—to find behavior-related gene expressions and compared them to known ARD-linked genes.
- The analysis revealed a significant correlation between the gene expressions related to behavior and ARD susceptibility, identifying a key molecular marker: an excess of Fcγ receptor IIb, which suppresses immune hyperactivation.
Article Synopsis
- GAGA (GAF) is a transcription factor crucial for regulating gene expression during fly development, and its underexpression in mutants leads to significant germline cell death and reduced testis size.
- Our RNA-seq analysis identified 2,437 differentially expressed genes in GAGA underexpressed testes, revealing downregulation of normal testis genes and an increase in stress-related genes.
- The study concludes that GAGA deficiency causes metabolic imbalances and impaired mitochondrial function, contributing to cellular stress and sperm cell death, but no specific GAGA-dependent cell death pathway was identified.
Article Synopsis
- Studies on the genetic basis of tame behavior during animal domestication highlight their relevance in both basic and applied research, especially in understanding behavior in domesticated species like gray rats.
- Researchers used high-throughput RNA sequencing to compare gene expression in the midbrains of tame versus aggressive rats, identifying 42 differentially expressed genes associated with behavior, including three transcription factors (TFs) that play significant roles.
- The expression of the TF gene Ascl3 in tame rats suggests a link to longer neurogenesis and neoteny, positioning ASCL3 as a key factor influencing behavioral changes during domestication.
Article Synopsis
- Hypertension often runs in families, but genetic research shows that known genetic factors only account for a small part of its heredity, prompting the need for more personalized treatment approaches.
- The study aimed to identify universal genetic markers for hypertension by analyzing gene expression in the brains of rats with different stress levels, linking stress reaction to hypertension risk.
- Findings revealed two potential biomarkers—β-protocadherins and hemoglobin—that are downregulated in hypertensive patients and could be used in broader hypertension management strategies.
Belyaev's concept of destabilizing selection during domestication was a major achievement in the XX century. Its practical value has been realized in commercial colors of the domesticated fox that never occur in the wild and has been confirmed in a wide variety of pet breeds. Many human disease models involving animals allow to test drugs before human testing.
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- The study used a web service to analyze SNPs in 68 genes related to rheumatoid arthritis (RA), identifying candidate markers that either contribute to or alleviate RA symptoms.
- Results suggested that both immunostimulatory and immunosuppressive genes are under natural selection, impacting RA risk levels in humans.
- The authors hypothesize that the evolution of RA in humans resembles patterns seen in domesticated animals, as RNA-Seq data revealed significant differences in gene expression between domestic pets and their wild counterparts linked to RA conditions.
Aggressiveness is a hereditary behavioral pattern that forms a social hierarchy and affects the individual social rank and accordingly quality and duration of life. Thus, genome-wide studies of human aggressiveness are important. Nonetheless, the aggressiveness-related genome-wide studies have been conducted on animals rather than humans.
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