Publications by authors named "Nataly Martynyuk"
Background: Vasopressin/oxytocin (VP/OT)-type neuropeptides are well known for their roles as regulators of diuresis, reproductive physiology and social behaviour. However, our knowledge of their functions is largely based on findings from studies on vertebrates and selected protostomian invertebrates. Little is known about the roles of VP/OT-type neuropeptides in deuterostomian invertebrates, which are more closely related to vertebrates than protostomes.
View Article and Find Full Text PDFArticle Synopsis
- Recent research highlights impaired endothelial function in chronic neurodegenerative diseases, including Alzheimer's, Huntington's, and Parkinson's disease, associated with α-synuclein aggregation.
- The study investigated the impact of misfolded α-synuclein preformed fibrils on endothelial cells and found significant disruptions in tight junction protein expression (like zona occludens-1 and occludin) due to neurotoxicity.
- Despite these disruptions, there was minimal evidence of functional impairments in endothelial cell function, suggesting that while misfolded α-synuclein affects the endothelial system, its exact role in Parkinson's disease remains unclear.