Regulation of Expression of Lymphocyte Activation Markers by Neutrophil Factors Secreted during Pregnancy.

The work was outlined to elucidate contribution of soluble factors produced by peripheral neutrophils from healthy pregnant women and those with EPH-gestosis to regulation of expression of surface activation markers by donor lymphocytes. It was found out that in healthy pregnant women neutrophil factors stimulated expression of HLA-DR and CD25 antigens by T lymphocytes. In women with EPH-gestosis neutrophil factors, which comprised soluble antigen of leukocytes 2 (SAL-2), enhanced expression of CD25 antigen in B subset.