Publications by authors named "Nataliya P Makarova"
Article Synopsis
- Despite advancements in biotechnological methods and ovarian stimulation protocols, the pregnancy success rate from in vitro fertilization (IVF) remains low at 30-40%.
- The study involved 110 subfertile couples undergoing IVF/ICSI, analyzing small noncoding RNA (sncRNA) in spent culture media from embryos at different developmental stages.
- Two logistic regression models demonstrated 100% accuracy in predicting embryo implantation potential using specific combinations of sncRNA, highlighting their role in regulating important cellular processes crucial for embryonic development.
Small noncoding RNAs (sncRNAs) are key regulators of the majority of human reproduction events. Understanding their function in the context of gametogenesis and embryogenesis will allow insight into the possible causes of in vitro fertilization (IVF) implantation failure. The aim of this study was to analyze the sncRNA expression profile of the spent culture media on day 4 after fertilization and to reveal a relationship with the morphofunctional characteristics of gametes and resultant embryos, in particular, with the embryo development and implantation potential.
View Article and Find Full Text PDFThe aim was to identify cell and genetic predictors of human blastocyst hatching success in assisted reproduction programmes via a prospective case-control study. Blastocysts, donated by couples in assisted reproduction programmes were used. Hatching success assessment was performed after 144-146 h post-fertilization.
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