Publications by authors named "Nataliya Libina"
Dietary restriction extends lifespan and inhibits reproduction in many species. In Caenorhabditis elegans, inhibiting reproduction by germline removal extends lifespan. Therefore, we asked whether the effect of dietary restriction on lifespan might proceed via changes in the activity of the germline.
View Article and Find Full Text PDFMany conditions that shift cells from states of nutrient utilization and growth to states of cell maintenance extend lifespan. We have carried out a systematic lifespan analysis of conditions that inhibit protein synthesis. We find that reducing the levels of ribosomal proteins, ribosomal-protein S6 kinase or translation-initiation factors increases the lifespan of Caenorhabditis elegans.
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- The Hutchinson-Gilford progeroid syndrome (HGPS) is primarily caused by a mutation in the LMNA gene that affects the production of lamin A, leading to premature aging symptoms.
- Researchers used RNA interference technology to target and suppress the expression of the harmful mutant protein Delta50 lamin A in HGPS fibroblast cells.
- The reduction of Delta50 lamin A levels resulted in improved cell health, offering a promising basis for developing gene therapy treatments for this syndrome.
In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different tissues interact to specify the lifespan of the animal.
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