- Health care facilities are threatened by a new human fungal pathogen that is resistant to many antifungal drugs and lacks effective diagnostic tools, leading to concerns about its genetic and phenotypic diversity across different regions.
- The study focuses on the gene expression differences in clinical isolates with varying antifungal resistance, using antifungal susceptibility screening and comparative transcriptional profiling to highlight significant variations.
- Findings indicate that even small changes in gene expression can influence drug response, and large-scale transcriptional profiling could assist in predicting the behavior of patient isolates, ultimately aiding in selecting more effective antifungal treatments.