The study of the hypoxia markers against the background of prolonged hyperglycemia in experimental animals.

Objective: Aim: The aim of article is to investigate the energetic functions of retinal mitochondria under conditions of chronic hyperglycemia to understand the pathogenic mechanisms involved in the development of this diabetic complication.

Patients And Methods: Materials and Methods: The experimental study was carried out on non-linear rats which were divided into 2 groups: intact animals and rats with diabetic retinopathy. We investigated the level of lactate, pyruvate and adenine nucleotides.