Porous polymeric scaffolds are used in tissue engineering to maintain or replace damaged biological tissues. Once embedded in body, they are involved into different physical and biological processes, among which their degradation and dissolution of their material can be singled out as one of the most important ones. Degradation parameters depend mostly on the properties of both the material and surrounding native tissues, which can substantially alter the original mechanical parameters of the scaffolds.
View Article and Find Full Text PDFApplications of additive manufacturing (AM) in tissue engineering develop rapidly. AM offers layer-by-layer creation of complex objects, developed to restore functionality of, or replace, damaged tissues. Porous 3D-printed functional gradient structures are of particular interest: their special architecture makes it possible to simulate the heterogeneity of the replaced tissue and, by continuously changing the mechanical properties, to avoid the concentration of stresses that can be caused by abrupt geometric changes.
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