Publications by authors named "Natalina E Elliott"
Article Synopsis
- Researchers developed a method to create organoids from induced pluripotent stem cells that mimic human bone marrow, which is crucial for studying blood formation and cancers.
- These 3D organoids replicate essential components of bone marrow and support the growth of cancer cells from patients, which are typically hard to maintain in lab settings.
- This innovative platform helps investigate blood cancers and their interactions within the bone marrow environment, aiding in the search for new treatments.
Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the first year of diagnosis. Both standard chemotherapy regimens and mAbs directed against ATLL tumor markers do not alter this aggressive clinical course. Therapeutic development would be facilitated by the discovery of genes and pathways that drive or initiate ATLL, but so far amenable drug targets have not been forthcoming.
View Article and Find Full Text PDF