[Pharmacokinetic modelling of valproate in epileptic patients].

Introduction: The aim of our study was to develop and use a population pharmacokinetic model for assessment of individual valproate clearance in children and young adults suffering from epilepsy.

Material And Methods: The analysis was performed using 52 steady-state concentrations of valproate collected from 26 epileptic patients during the routine clinical practice in our hospital. The mean values of age and total body weight were 19.

Inverse correlation of valproic acid serum concentrations and quality of life in adolescents with epilepsy.

Background: Correlation between steady-state serum concentrations of antiepileptic drugs and both seizure control and adverse drug reactions frequency (two major determinants of quality of life in patients with epilepsy) is still matter of controversy.

Objective: The aim of our study was to investigate whether a correlation exists between steady-state serum concentration of valproic acid and quality of life in adolescent patients with epilepsy.

Method: Twenty-one adolescent patients with epilepsy, treated with valproic acid for more than 6 months entered the study.