Novel isoniazid derivative as promising antituberculosis agent.

A major focus of tuberculosis drug discovery is aimed at the development of novel antibiotics with activity against drug-resistant strains of . We have synthesized ten isoniazid derivatives and investigated for antibacterial activity toward H37Rv and isoniazid-resistant strain SRI 1369. It was revealed that only one compound, isonicotinic acid (1-methyl-1H-pyrrol-2-ylmethylene)-hydrazide (), is active toward isoniazid-resistant strain with minimum inhibitory concentration value of 0.

Benzaldehyde thiosemicarbazone derivatives against replicating and nonreplicating Mycobacterium tuberculosis.

In this article, we report a series of benzaldehyde thiosemicarbazone derivatives possessing high activity toward actively replicating Mycobacterium tuberculosis strain with minimum inhibitory concentration (MIC) values in the range from 0.14 to 2.2 μM.