Publications by authors named "Natalie Scheurmann"
Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist.
Seppe Vander Beken Juliane C de Vries Barbara Meier-Schiesser Patrick Meyer Dongsheng Jiang Natalie J Scheurmann
Stem Cells
August 2019
Article Synopsis
- - The study identifies a specific group of dermal cells, ABCB5-derived mesenchymal stem cells (MSCs), that effectively aid in healing nonhealing wounds by reducing inflammation caused by macrophages.
- - The healing properties are attributed to the secretion of interleukin-1 receptor antagonist (IL-1RA) by these MSCs, which shifts inflammation from harmful pro-inflammatory (M1) macrophages to protective anti-inflammatory (M2) macrophages.
- - Human ABCB5 cells are proposed as a promising source of MSCs for treating chronic nonhealing wounds, evidenced by their effective results in a mouse model that simulates human venous leg ulcers.
Background: Hand eczema, which is frequently caused by delayed-type allergy, is treated with 9-cis-retinoic acid (9cisRA). However, knowledge on how 9cisRA modulates skin immunity is sparse.
Objective: As dendritic cells (DCs) are central in the pathogenesis of contact allergy, we investigated 9cisRA modulation of DC function in murine contact hypersensitivity (CHS).