Publications by authors named "Natalie R Case"
Article Synopsis
- The study investigates the role of p16(INK4a) in cell cycle regulation and its absence in human mammary epithelial cells, which may lead to increased risk of breast cancer through various dysfunctions and DNA methylation changes.
- Researchers tested for hypermethylation of the INK4a/ARF promoter in breast tissue samples from 86 asymptomatic women at high risk for breast cancer, alongside evaluating correlation with other methylation markers.
- Results showed that INK4a/ARF promoter hypermethylation occurs in early stages of neoplasia and normal cells, indicating a potential indicator of broader methylation issues in breast cancer risk, rather than being solely an age-related change.
Introduction: A method to measure the mucin concentration in bronchoalveolar lavage (BAL) fluid was developed to aid efforts to identify pharmacologically the mechanisms that modulate pathophysiological mucin secretion. Mucins are the major macromolecular components of mucus. In the airways, mucus is the first line of defense against inhaled microorganisms (infection) and particulates (irritation).
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