Publications by authors named "Natalie Noble"
GPCR-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. While experiments in transfected cells often reveal selectivity for individual neurotransmitters, sensor specificity in the brain frequently remains uncertain. Pursuing experiments in brain slices and in vivo, we find that norepinephrine and dopamine cross-activate the respective sensors.
View Article and Find Full Text PDFObjectives: Despite the development of efficacious wellness interventions, sustainable wellness behavior change remains challenging. To optimize engagement, initiating small behaviors that build upon existing practices congruent with individuals' lifestyles may promote sustainable wellness behavior change. In this study, we crowd-sourced helpful, flexible, and engaging wellness practices to identify a list of those commonly used for improving sleep, productivity, and physical, emotional, and social wellness from participants who felt they had been successful in these dimensions.
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- PTSD primarily affects females and is linked to altered brain connectivity, differing from previous findings in males.
- The study involved 61 women who had experienced trauma, utilizing resting EEG data to measure brain connectivity.
- Results indicated that women with PTSD showed increased connectivity in certain brain regions, particularly those related to visual processing and attention, with hormonal factors potentially influencing these patterns.
Learning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they are regulated are unclear. In this study, to monitor how depolarization impacts local dendritic biology, we employed a dendritically targeted proximity labeling approach followed by crosslinking immunoprecipitation, ribosome profiling and mass spectrometry. Depolarization of primary cortical neurons with KCl or the glutamate agonist DHPG caused rapid reprogramming of dendritic protein expression, where changes in dendritic mRNAs and proteins are weakly correlated.
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- PTSD and depression are linked to a higher risk of cardiovascular disease (CVD), especially in women with a history of trauma.
- This study examined the connections between cardiovascular health and symptoms of PTSD and depression in 49 individuals assigned female at birth, all of whom experienced significant trauma.
- Results showed that trauma exposure correlated with higher blood pressure, and CVD symptoms were significantly related to PTSD, depression, and anhedonia, indicating a need for further research on how treating these mental health issues could affect CVD risk.
Article Synopsis
- * A study involving 80 trauma-exposed Black women assessed the relationship between PTSD symptoms, cardiovascular health (specifically endothelial function), and glucose tolerance using various tests and measures.
- * Findings revealed a significant association between endothelial function and PTSD symptoms, particularly at lower levels of respiratory sinus arrhythmia, highlighting the need for further research on how cardiovascular health impacts metabolic function in women with PTSD and type-2 diabetes.
Recovery after stroke is thought to be mediated by adaptive circuit plasticity, whereby surviving neurons assume the roles of those that died. However, definitive longitudinal evidence of neurons changing their response selectivity after stroke is lacking. We sought to directly test whether such functional "remapping" occurs within mouse primary somatosensory cortex after a stroke that destroys the C1 barrel.
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