Pharmacodynamic model of slow reversible binding and its applications in pharmacokinetic/pharmacodynamic modeling: review and tutorial.

Therapeutic responses of most drugs are initiated by the rate and degree of binding to their receptors or targets. The law of mass action describes the rate of drug-receptor complex association (k) and dissociation (k) where the ratio k/k is the equilibrium dissociation constant (K). Drugs with slow reversible binding (SRB) often demonstrate delayed onset and prolonged pharmacodynamic effects.