Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer.

Diet is a robust entrainment cue that regulates diurnal rhythms of the gut microbiome. We and others have shown that disruption of the circadian clock drives the progression of colorectal cancer (CRC). While certain bacterial species have been suggested to play driver roles in CRC, it is unknown whether the intestinal clock impinges on the microbiome to accelerate CRC pathogenesis.

Rotational multimaterial printing of filaments with subvoxel control.

Helical structures are ubiquitous in nature and impart unique mechanical properties and multifunctionality. So far, synthetic architectures that mimic these natural systems have been fabricated by winding, twisting and braiding of individual filaments, microfluidics, self-shaping and printing methods. However, those fabrication methods are unable to simultaneously create and pattern multimaterial, helically architected filaments with subvoxel control in arbitrary two-dimensional (2D) and three-dimensional (3D) motifs from a broad range of materials.

Programmed shape-morphing into complex target shapes using architected dielectric elastomer actuators.

Dielectric elastomer actuators (DEAs) are among the fastest and most energy-efficient, shape-morphing materials. To date, their shapes have been controlled using patterned electrodes or stiffening elements. While their actuated shapes can be analyzed for prescribed configurations of electrodes or stiffening elements (the forward problem), the design of DEAs that morph into target shapes (the inverse problem) has not been fully addressed.

Insight into 3D micro-CT data: exploring segmentation algorithms through performance metrics.

Three-dimensional (3D) micro-tomography (µ-CT) has proven to be an important imaging modality in industry and scientific domains. Understanding the properties of material structure and behavior has produced many scientific advances. An important component of the 3D µ-CT pipeline is image partitioning (or image segmentation), a step that is used to separate various phases or components in an image.

Early onset scoliosis: what the primary care provider needs to know and implications for practice.

Purpose: The purpose of this article is to discuss the role of the primary care provider in the detection of and referral for early onset scoliosis. An overview of scoliosis including etiology, natural history, guidelines for physical examination, current practice for scoliosis screening, and available treatments will be discussed.

Data Sources: PubMed, OVID Medline, Psychinfo.