Publications by authors named "Natalie Karp"
Obesity and Native Tissue Repairs: A Secondary Analysis of the OPTIMAL Trial.
Urogynecology (Phila)
January 2025
Article Synopsis
- The OPTIMAL Trial evaluated the effectiveness of two surgical techniques, sacrospinous ligament fixation (SSLF) and uterosacral ligament suspension (ULS), for treating pelvic organ prolapse and how obesity affects these outcomes.
- The study found no significant differences in surgical failure rates between the two techniques across various BMI categories, but there was a noted increase in failure rates for ULS as BMI increased.
- The conclusion suggests that while neither surgical method showed a clear advantage in different BMI groups, further research is needed to determine which procedure may be better for obese patients.
Article Synopsis
- *Such fistulas have been associated with issues like retained intrauterine devices, neglected pessaries, and unusual sexual practices or psychological conditions.
- *This text highlights the first known case of both bilateral ureterovaginal and vesicovaginal fistulas occurring together due to a retained pessary.
Article Synopsis
- Rectovaginal fistulas can result from various causes, both obstetric and nonobstetric, and understanding the factors that influence repair success is crucial for patient counseling.
- A study analyzed outcomes from transperineal rectovaginal fistula repairs conducted on women at the University of Michigan between 2005 and 2015, showing that nonobstetric causes significantly increased the risk of repair failure.
- The research found that 22.7% of repairs failed, with nonobstetric fistulas having a relative risk of 3.53 for failure compared to obstetric ones, providing valuable insights for surgeons when discussing treatment options.
Length of Catheter Use After Hysterectomy as a Risk Factor for Urinary Tract Infection.
Female Pelvic Med Reconstr Surg
April 2019
Article Synopsis
- The study aimed to assess how the length of time a catheter is used after hysterectomy affects the risk of urinary tract infections (UTIs) and to identify potential risk factors for developing a UTI post-surgery.
- Using a retrospective case-control approach, the researchers analyzed patient data to find trends related to catheter duration and UTI occurrences within 30 days after surgery.
- Results showed that UTI risk increased with longer catheter exposure, highlighting that high and highest catheter use, along with longer operative times and certain surgical procedures, significantly raised the likelihood of developing a UTI.
Removal of normal ovaries in women under age 51 at the time of hysterectomy.
Am J Obstet Gynecol
November 2015
Article Synopsis
- The study investigates why normal ovaries are often removed during hysterectomies in women under 51, despite recommendations for ovarian conservation in low-risk cases.
- Out of 6,789 subjects, 44.2% underwent oophorectomy, with 23.1% of those having normal ovaries; the method of surgery and age were significant factors influencing this decision.
- Vaginal hysterectomies had lower rates of normal ovary removal compared to laparoscopic and abdominal methods, and a family history of cancer increased the likelihood of oophorectomy.
Article Synopsis
- * Food deprivation did not impact NULLs' predation capabilities, suggesting that LACTs' enhanced hunting skills are not solely due to increased hunger, while sensory factors like olfaction and hearing played a minimal role.
- * The research highlighted the importance of visual stimuli in enhancing predation in LACTs, showing that testing in low light reduced their hunting advantage, and also noted improved predatory behavior in pregnant rats at certain stages of pregnancy.
Article Synopsis
- Researchers examined whether Delta(9)-THC and anandamide provide similar effects as cues for rats in a discrimination task, but previous findings have been inconsistent due to anandamide’s instability.
- To address this, they trained rats using O-1812, a stable analog of anandamide, alongside Delta(9)-THC.
- Results indicated that while O-1812 and Delta(9)-THC showed similar effects, O-1812 worked better at lower doses and influences of certain blockers affected their responses differently, highlighting both similarities and distinct differences in their effects.