Publications by authors named "Natalie J Hughes-Medlicott"
Article Synopsis
- A study examined the effects of intramuscular (IM) ketamine on treatment-resistant Obsessive-Compulsive Disorder (OCD), comparing it to IM fentanyl.
- The results showed that ketamine significantly reduced OCD symptoms, as measured by the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), especially at higher doses.
- Although ketamine was associated with short-term dissociative effects, this research provides promising evidence for its use in managing severe OCD, suggesting that further studies are needed for optimal dosing and long-term effects.
Oral docetaxel plus encequidar - A pharmacokinetic model and evaluation against IV docetaxel.
J Pharmacokinet Pharmacodyn
August 2024
Article Synopsis
- This study explored the feasibility of using an oral formulation of docetaxel combined with encequidar (oDox+E) as an alternative to the traditional intravenous (IV) dosage in cancer treatment, aligning with FDA's Project Optimus for improved drug development.
- A population pharmacokinetic model was created to analyze how different dosing regimens of oDox+E compared to IV docetaxel in terms of achieving effective plasma concentrations, with a focus on reaching a target attainment probability (PTA) of 80% or higher.
- Results indicated that while single-dose regimens of oDox+E fell short of the 80% PTA threshold, two- and
Background: The N-methyl-D-aspartate antagonist ketamine has rapid onset antidepressant activity in treatment-resistant depression (TRD).
Aims: To evaluate mood rating, safety and tolerability data from patients with TRD treated with ketamine and the psychoactive control fentanyl, as part of a larger study to explore EEG biomarkers associated with mood response.
Methods: We evaluated the efficacy and safety of intramuscular racemic ketamine in 25 patients with TRD, using a double-blind active-controlled randomized crossover design.
Australasia is home to unique and endangered avian species. Drug administration to this group of animal patients for prophylaxis and treatment is challenging from a number of different perspectives. A key limitation for optimal drug dosing in birds is the lack of published pharmacokinetic studies to guide dose requirements.
View Article and Find Full Text PDFBackground: The importance of wildlife health has been critically emphasized by the current global pandemic. Pharmacists play a valuable role in the health care of companion animals and livestock; however, their involvement in exotic animal health is largely unexplored.
Objectives: This project consulted with zoo vets in New Zealand and investigated their practices around prescribing and dispensing of medicines to explore the opportunities for the involvement of pharmacists.