Publications by authors named "Natalie Hughes-Medlicott"
Article Synopsis
- A study examined the effects of intramuscular (IM) ketamine on treatment-resistant Obsessive-Compulsive Disorder (OCD), comparing it to IM fentanyl.
- The results showed that ketamine significantly reduced OCD symptoms, as measured by the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), especially at higher doses.
- Although ketamine was associated with short-term dissociative effects, this research provides promising evidence for its use in managing severe OCD, suggesting that further studies are needed for optimal dosing and long-term effects.
Introduction: Docetaxel, a taxane used in the treatment of solid tumours, exerts pharmacological activity when in its unbound form. We report a sensitive assay to quantify unbound docetaxel after oral administration of docetaxel plus encequidar (oDox+E). Unbound drug quantification is important due to its direct correlation with drug-related toxicity and therapeutic efficacy.
View Article and Find Full Text PDFOral docetaxel plus encequidar - A pharmacokinetic model and evaluation against IV docetaxel.
J Pharmacokinet Pharmacodyn
August 2024
Article Synopsis
- This study explored the feasibility of using an oral formulation of docetaxel combined with encequidar (oDox+E) as an alternative to the traditional intravenous (IV) dosage in cancer treatment, aligning with FDA's Project Optimus for improved drug development.
- A population pharmacokinetic model was created to analyze how different dosing regimens of oDox+E compared to IV docetaxel in terms of achieving effective plasma concentrations, with a focus on reaching a target attainment probability (PTA) of 80% or higher.
- Results indicated that while single-dose regimens of oDox+E fell short of the 80% PTA threshold, two- and
Background: The N-methyl-D-aspartate antagonist ketamine has rapid onset antidepressant activity in treatment-resistant depression (TRD).
Aims: To evaluate mood rating, safety and tolerability data from patients with TRD treated with ketamine and the psychoactive control fentanyl, as part of a larger study to explore EEG biomarkers associated with mood response.
Methods: We evaluated the efficacy and safety of intramuscular racemic ketamine in 25 patients with TRD, using a double-blind active-controlled randomized crossover design.
Australasia is home to unique and endangered avian species. Drug administration to this group of animal patients for prophylaxis and treatment is challenging from a number of different perspectives. A key limitation for optimal drug dosing in birds is the lack of published pharmacokinetic studies to guide dose requirements.
View Article and Find Full Text PDFIntroduction: Decisions about using psychotropics during pregnancy are complex as risks of untreated illness are balanced against risks of fetal exposure to medication. The objective was to describe perinatal psychotropic dispensing patterns in New Zealand.
Methods: Nationwide data from the New Zealand National Maternity Collection between January 1, 2011 and December 31, 2017 identified 399 715 pregnancies.
Background: The importance of wildlife health has been critically emphasized by the current global pandemic. Pharmacists play a valuable role in the health care of companion animals and livestock; however, their involvement in exotic animal health is largely unexplored.
Objectives: This project consulted with zoo vets in New Zealand and investigated their practices around prescribing and dispensing of medicines to explore the opportunities for the involvement of pharmacists.