Publications by authors named "Natalie Grindrod"
Cardiac myxomas, the most common primary cardiac tumors, are believed to originate from multipotent mesenchymal cells. Approximately 75% of myxomas occur within the left atrium, increasing the risk of systemic thromboembolic events. While typically benign, atrial myxomas can rarely metastasize to the brain, with fewer than 60 cases reported.
View Article and Find Full Text PDFBackground: The search for rare elements, like mitotic figures, is crucial in pathology. Combining digital pathology with eye-tracking technology allows for the detailed study of how pathologists complete these important tasks.
Objectives: To determine if pathologists have distinct search characteristics in domain- and nondomain-specific tasks.
A Prognostic Index for Liver Radiation (PILiR) for improved patient selection for stereotactic liver-directed radiotherapy (SBRT) was developed. Using a large single-center database, 195 patients treated with SBRT for local control, including 66 with hepatocellular carcinoma (HCC) and 129 with metastatic liver disease, were analyzed. Only patients ineligible for alternative treatments were included.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the expression of HER2, an important biomarker for identifying and treating several types of cancers, including breast and gastroesophageal cancers, and its emerging relevance in other cancer types.
- Conducted at a Canadian academic cancer center, the research sampled 499 solid tumors from adult patients between July 2020 and November 2023, excluding standard HER2-targeted malignancies.
- Results indicated that HER2 expression levels varied across 42 cancer types, with a median turnaround time for test results being 18 days, which aligns with the feasibility for clinical decision-making.
Cholangiocarcinoma (CCA) is a rare cancer of bile ducts. It is associated with a poor prognosis. The incidence of CCA is rising worldwide.
View Article and Find Full Text PDFBackground: A number of therapeutic treatment strategies exist for patients with hepatocellular carcinoma (HCC) and portal vein thrombosis (PVT). The aim of this review is to provide a current understanding of treatment options and determine the relative effectiveness of treatment options in preventing mortality over 24 months.
Methods: A search was conducted in PubMed, EMBASE and Cochrane CENTRAL from 2007 to 2022.