Performance of Closed-Loop DBS During Sleep in Patients with Essential Tremor.

Deep Brain Stimulation (DBS) has emerged as an effective therapy for people suffering from medication refractory essential tremor (ET). Significant tremor suppression for patients can be achieved by targeting and stimulating the thalamic ventral intermediate nucleus (VIM). In clinical practice, DBS is delivered continuously, resulting in stimulation when not needed, particularly during sleep when tremor is not experienced.