Publications by authors named "Natalie G Snider"
Area-level Socioeconomic Disadvantage and Cancer Survival in Metropolitan Detroit.
Cancer Epidemiol Biomarkers Prev
March 2023
Background: Racial segregation is linked to poorer neighborhood quality and adverse health conditions among minorities, including worse cancer outcomes. We evaluated relationships between race, neighborhood social disadvantage, and cancer survival.
Methods: We calculated overall and cancer-specific survival for 11,367 non-Hispanic Black (NHB) and 29,481 non-Hispanic White (NHW) individuals with breast, colorectal, lung, or prostate cancer using data from the Metropolitan Detroit Cancer Surveillance System.
Article Synopsis
- - ERCC1/XPF is an important protein for repairing DNA damage caused by certain chemotherapy drugs, and researchers found that lung cancer cells lacking ERCC1 and p53 can resist platinum-based chemotherapy.
- - Inhibiting ATR, a protein that helps maintain DNA replication, restored sensitivity to platinum in these resistant cells by affecting replication fork protection and cell cycle checkpoints.
- - Combining ATR inhibitors with platinum treatment not only increased DNA damage but also showed promise for enhancing immunotherapy effectiveness, making it a potential strategy to treat ERCC1-deficient lung cancers.