Purpose Of Review: This article describes the clinical presentation, relevant diagnostic investigations, and treatment of metabolic and toxic myelopathies.
Recent Findings: Metabolic myelopathies, including those due to deficiency of vitamin B12, folate, copper, or vitamin E, are preventable and typically respond to supplementation. In metabolic myelopathy, early recognition and treatment are important to reduce morbidity, particularly due to subacute combined degeneration of the spinal cord.