The brain-penetrant 5-HT receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain.

Neuropathic pain is a debilitating pathological condition of high clinical relevance. Changes in neuronal excitability in the anterior cingulate cortex (ACC) play a central role in the negative emotional and affective aspects of chronic pain. We evaluated the effects of LP-211, a new serotonin-receptor-type-7 (5-HTR) agonist that crosses the blood-brain barrier, on ACC neurons in a mouse model of neuropathic pain.