Publications by authors named "Natalie Crowe"
Article Synopsis
- miR-140 is primarily found in cartilage, and its complete deletion in mice leads to growth issues and early signs of arthritis; however, the specific roles of its two forms, miR-140-5p and miR-140-3p, remain unclear.
- A study using small RNA sequencing showed that miR-140-3p is over ten times more abundant than miR-140-5p in human cartilage, with several variations (isomiRs) identified.
- Experimental results demonstrated that the newly identified isomiR, miR-140-3p.1, has a stronger impact on gene regulation than the typical miR-140-3p, affecting hundreds of genes related to cartilage
Unlabelled: MicroRNAs have been shown to function in cartilage development and homeostasis, as well as in progression of osteoarthritis. The objective of the current study was to identify microRNAs involved in the onset or early progression of osteoarthritis and characterise their function in chondrocytes. MicroRNA expression in mouse knee joints post-DMM surgery was measured over 7 days.
View Article and Find Full Text PDFeIF4A is a highly conserved RNA-stimulated ATPase and helicase involved in the initiation of mRNA translation. The Arabidopsis genome encodes two isoforms, one of which (eIF4A-1) is required for the coordination between cell cycle progression and cell size. A T-DNA mutant eif4a1 line, with reduced eIF4A protein levels, displays slow growth, reduced lateral root formation, delayed flowering and abnormal ovule development.
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