NAADP-Evoked Ca Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes.

Huntington's disease (HD) is a progressive neurodegenerative disease characterized by mutations in the huntingtin gene (mHtt), causing an unstable repeat of the CAG trinucleotide, leading to abnormal long repeats of polyglutamine (poly-Q) in the N-terminal region of the huntingtin, which form abnormal conformations and aggregates. Alterations in Ca signaling are involved in HD models and the accumulation of mutated huntingtin interferes with Ca homeostasis. Lysosomes are intracellular Ca storages that participate in endocytic and lysosomal degradation processes, including autophagy.

The phosphorylation status and cytoskeletal remodeling of striatal astrocytes treated with quinolinic acid.

Quinolinic acid (QUIN) is a glutamate agonist which markedly enhances the vulnerability of neural cells to excitotoxicity. QUIN is produced from the amino acid tryptophan through the kynurenine pathway (KP). Dysregulation of this pathway is associated with neurodegenerative conditions.