Publications by authors named "Natalia Zemlianskaia"
Article Synopsis
- * Researchers analyzed data from 52 studies, including nearly 31,000 CRC cases and over 41,000 controls, to explore the genetic interactions with regular aspirin/NSAID use.
- * They found significant interactions with genetic variants in two specific regions (6q24.1 and 5p13.1), which could help uncover new targets for understanding how aspirin provides its protective effects against colorectal cancer.
Article Synopsis
- This study explores how genetics and body mass index (BMI) interact to influence colorectal cancer risk, analyzing data from over 84,000 participants.
- The research identifies a significant genetic marker (rs58349661) in the FMN1/GREM1 gene region that shows a strong connection with increased cancer risk in individuals with higher BMI, particularly among those with a specific genotype.
- Findings suggest that understanding this gene-environment interaction could help develop more tailored prevention strategies for colorectal cancer related to obesity.
We describe a regularized regression model for the selection of gene-environment (G×E) interactions. The model focuses on a single environmental exposure and induces a main-effect-before-interaction hierarchical structure. We propose an efficient fitting algorithm and screening rules that can discard large numbers of irrelevant predictors with high accuracy.
View Article and Find Full Text PDFDurability of Protection Post-Primary COVID-19 Vaccination in the United States.
Vaccines (Basel)
September 2022
The durability of immune responses after COVID-19 vaccination will drive long-term vaccine effectiveness across settings and may differ by vaccine type. To determine durability of protection of COVID-19 vaccines (BNT162b2, mRNA-1273, and Ad26.COV2.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the genetic and environmental interactions influencing colorectal cancer risk, focusing on the J-shaped relationship with alcohol consumption, distinguishing between nondrinkers, light-to-moderate drinkers, and heavy drinkers.
- - By pooling data from major cancer registries, the researchers identified 13 significant SNPs in the 10q24.2/COX15 region, showing that the A allele of SNP rs2300985 increases colorectal cancer risk for light-to-moderate drinkers compared to nondrinkers and heavy drinkers.
- - The findings suggest that the strongest genetic association with colorectal cancer occurs in nondrinkers, with SNP rs1318920 predicted as a potential causal regulatory variant impacting cancer risk.