Publications by authors named "Natalia Zapata"
Introduction: Outcomes of human immunodeficiency virus (HIV) infected patients admitted to intensive care units (ICU) have improved with antiretroviral therapy (ART). However, whether the outcomes have improved in low- and middle-income countries, paralleling those of high-income countries is unknown. The objective of this study was to describe a cohort of HIV-infected patients admitted to ICU in a middle-income country and identify the risk factors associated with mortality.
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- Rhinosporidiosis is a chronic infection caused by the parasite Rhinosporidium seeberi, mainly presenting as nasal or eye-related growths, particularly in tropical and subtropical regions.
- A systematic study analyzed cases from 1896 to 2019, reviewing 1,994 reports and focusing on 286 cases in the Americas, with the highest occurrences in Brazil and Colombia.
- The review highlights significant differences between American and Asian cases, including a higher incidence of ocular issues and increased rates of recurrence after surgical treatment.
MicroRNAs (miRNAs), small non-coding RNAs that fine-tune gene expression, play multiple roles in the cell, including cell fate specification. We have analyzed the differential expression of miRNAs during fibroblast reprogramming into induced pluripotent stem cells (iPSCs) and endoderm induction from iPSCs upon treatment with high concentrations of Activin-A. The reprogrammed iPSCs assumed an embryonic stem cell (ESC)-like miRNA signature, marked by the induction of pluripotency clusters miR-290-295 and miR-302/367 and conversely the downregulation of the let-7 family.
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