Publications by authors named "Natalia Yu Sherina"
Article Synopsis
- Previous studies suggest that founder mutations contribute significantly to breast cancer risk in Russia.
- A systematic analysis was conducted on 302 breast cancer cases, focusing on specific hereditary indicators such as early onset and family history.
- The study identified that 15.2% of patients carried mutations linked to breast cancer, with the BRCA1 5382insC mutation being the most common among them, highlighting the potential of targeted genetic testing for diagnosis.
BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients.
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