Pluronic P123/DMSO Lyotropic Liquid Crystal for Incorporating Bioactive Substances for Topical Application.

Lyotropic liquid crystals (LLCs) have attracted considerably growing interest in drug delivery applications over the last years. The structure of LLC matrices is complementary to cell membranes and provides an efficient, controlled, and selective release of drugs. In this work, a complex of experimental methods was used to characterize binary LLCs Pluronic P123/DMSO and triple LLC systems Pluronic P123/DMSO/Ibuprofen, which are interesting as transdermal drug delivery systems.

New substituted 1,2,3-triazoles for ratiometric recognition to Fe ions.

Two novel click derived sensory systems for different derivatives connected via a triazole linkage have been developed as a component of a chemosensor with sensitive towards Fe ions. The 1-octyl-4-carboxyl-1,2,3-triazole (TR1) system demonstrated sensitivity to calcium ion. The 1,3-bis(4-hydroxycarbamoyl-1,2,3-triazol-1-yl)xylylene (TR2) system was shown to possess a preferential detection capability as a colorimetric probe for Fe ions by exhibiting an obvious pH-dependent color change from colorless to pink.

Immunomodulatory Activity of Polysaccharides Isolated from L. and Ledeb.

The genus has been used in the preparation of therapies for a number of medical problems, yet not much is known about the therapeutic high-molecular-weight compounds present in extracts from these plants. Since polysaccharides are important in immune modulation, we investigated the chemical composition and immunomodulatory activity of L. and Ledeb polysaccharides.

Enzymatic Conversions of Glutamate and γ-Aminobutyric Acid as Indicators of Plant Stress Response.

Glutamate plays a central role in amino acid metabolism, in particular, in aminotransferase reactions leading to formation of many other proteinogenic and nonproteinogenic amino acids. In stress conditions, glutamate can be either metabolized to γ-aminobutyric acid (GABA) by glutamate decarboxylase which initiates a GABA shunt bypassing several reactions of the tricarboxylic acid cycle or converted to 2-oxoglutarate by glutamate dehydrogenase. Both reactions direct protein carbon to respiration but also link glutamate metabolism to other cellular pathways, resulting in the regulation of redox level and pH balance.

Luminescent complexes of terbium ion for molecular recognition of ibuprofen.

The complexation behavior and luminescent properties of terbium (Tb(3+) ) complexes containing bi-dental ligands were studied: nitrogen - 1,10-phenanthroline, and oxygen - trifluoroacetylacetone as well as acetylacetone ligands with ibuprofen (Ibu; a non-steroidal anti-inflammatory drug). Aqueous and aqueous alcohol microheterogeneous solutions were used as media. The effects of solubilization by various micellar solutions, pH and ligand type on luminescent properties of Tb(3+) complexes were investigated.

N,N-dimethyldodecylamine oxide self-organization in the presence of lanthanide ions in aqueous and aqueous-decanol solutions.

The article represents the results of research in self-organization of new lanthanide systems in water-decanol medium. The systems are based on N,N-dimethyldodecylamine oxide, a zwitterionic surfactant. The study covers the complex formation of lanthanide ions with C12DMAO molecules and the influence of Ln(III) ions and medium composition on surfactant association in diluted solutions.

Mesogenic and luminescent properties of lyotropic liquid crystals containing Eu(III) and Tb(III) ions.

Lyotropic metallomesogens containing trivalent rare-earth metal ions have unique attractive behavior due to the combination of some specific properties of the lanthanide ions with anisotropic supramolecular organization liquid crystal and provide new promises in biochemistry and materials science. In this article, we have studied the liquid crystal and luminescence properties of lyotropic systems containing Eu(III) and Tb(III) ions based on nonionic surfactants. The type, the structural parameters of the mesophases, and the structure of a liquid crystal complex have been investigated using polarized optical microscopy (POM), X-ray diffraction, and Fourier transform infrared.