Following changes in brain structure and function with multimodal MRI in a year-long prospective study on the development of Type 2 diabetes.

Aims: To follow disease progression in a rat model of Type 2 diabetes using multimodal MRI to assess changes in brain structure and function.

Material And Methods: Female rats ( = 20) were fed a high fat/high fructose diet or lab chow starting at 90 days of age. Diet fed rats were given streptozotocin to compromise pancreatic beta cells, while chow fed controls received vehicle.