Publications by authors named "Natalia Paulenka Ivanovova"
Detecting IgE sensitizations in the serum of allergic dogs is commonly performed using allergen extracts, but these are difficult to standardize. This article details the development and validation of the Pet Allergy Xplorer (PAX; Nextmune, Stockholm, Sweden), the first multiplex macroarray for the detection of IgE sensitization in dogs using allergen extracts and molecular components; the PAX is derived from the Allergy Xplorer (ALEX; MacroArray Diagnostics, Vienna, Austria). The selection of allergens, cartridge processing, strategy for identifying and blocking IgE directed against cross-reactive carbohydrate determinants (CCDs), and the method used for determining the positivity threshold are described.
View Article and Find Full Text PDFTau protein is an intrinsically disordered protein. Its physiological state is best described as a conformational ensemble (CE) of metastable structures interconverting on the local and molecular scale. The monoclonal antibody DC39C recognizes a linear C-terminal tau epitope, and as the tau interaction partner, its binding parameters report about tau CE.
View Article and Find Full Text PDFBackground: The emergence of new SARS-CoV-2 variants of concern B.1.1.
View Article and Find Full Text PDFNeurodegeneration is associated with hypertension and disturbance in fat metabolism. The complex interaction of neurodegenerative processes with both metabolic changes and blood pressure is still not fully elucidated. Here we demonstrate that the experimentally induced tauopathy in hypertensive transgenic animals causes significant downregulation of plasma leptin (53% of control), reduction of body weight by 11%, a 1.
View Article and Find Full Text PDFArticle Synopsis
- - The ADAMANT trial studied AADvac1, a new vaccine targeting abnormal tau protein in Alzheimer’s disease, administered as 11 doses to patients with mild dementia over 24 months, focusing on safety, tolerability, and effectiveness.
- - A total of 196 participants were enrolled, with AADvac1 found to be safe and well tolerated, showing some adverse events but lower serious cases compared to placebo.
- - Although the vaccine stimulated a strong immune response, there were no significant improvements in cognitive function or clinical outcomes across the entire study group, indicating a need for more extensive research in specific subgroups to assess its efficacy.
Article Synopsis
- The relationship between Alzheimer's disease (AD) and obesity is well-documented, yet the specific mechanisms linking brain degeneration and fat metabolism remain unclear.
- This study found that rats with progressive neurofibrillary pathology—indicative of AD—showed significantly lower levels of leptin, a hormone related to fat regulation, suggesting a link between obesity and AD.
- The results indicate that decreased plasma leptin could serve as a potential biomarker for Alzheimer's disease, and further understanding of this relationship might lead to better diagnostic and treatment options for patients.