Assessment of CRISPRa-mediated overexpression in an Parkinson's disease model.

Introduction: Parkinson's disease (PD) presents a significant challenge in medical science, as current treatments are limited to symptom management and often carry significant side effects. Our study introduces an innovative approach to evaluate the effects of overexpression mediated by CRISPRa in an model of Parkinson's disease. The expression of can have neuroprotective effects, being related to the modulation of neuroinflammation and pathways associated with cell survival, differentiation, and growth.

Divergence in brain size and brain region volumes across wild guppy populations.

Complex evolutionary dynamics have produced extensive variation in brain anatomy in the animal world. In guppies, , brain size and anatomy have been extensively studied in the laboratory contributing to our understanding of brain evolution and the cognitive advantages that arise with brain anatomical variation. However, it is unclear whether these laboratory results can be translated to natural populations.

Understanding the Potential of Genome Editing in Parkinson's Disease.

CRISPR is a simple and cost-efficient gene-editing technique that has become increasingly popular over the last decades. Various CRISPR/Cas-based applications have been developed to introduce changes in the genome and alter gene expression in diverse systems and tissues. These novel gene-editing techniques are particularly promising for investigating and treating neurodegenerative diseases, including Parkinson's disease, for which we currently lack efficient disease-modifying treatment options.