Publications by authors named "Natalia N Sukhanova"
Background: The majority of miscarriages are sporadic; however, 1-5% of couples experience recurrent pregnancy loss (RPL). Approximately 50-60% of miscarriages result from chromosomal abnormalities. Currently, there are conflicting reports regarding the rates of chromosomal abnormalities between recurrent and sporadic pregnancy losses.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to create a mathematical model to better estimate chromosomal abnormalities and sex ratio in spontaneous abortions affected by maternal cell contamination.
- Researchers analyzed 112 samples of spontaneous abortions and identified Y chromosome DNA in 16% of embryos categorized as "46,XX," suggesting contamination may skew results.
- The findings indicate that accounting for maternal cell contamination is crucial, as it significantly alters the perceived rates of chromosomal abnormalities and sex ratios, which is important for future diagnostic practices.
Cytogenetic analysis of reproductive wastage is an important stage in understanding the genetic background of early embryogenesis. The results of conventional cytogenetic studies of spontaneous abortions depend on tissue culturing and are associated with a significant cell culture failure rate. We performed interphase dual-colour FISH analysis to detect chromosomal abnormalities in noncultured cells from two different tissues-cytotrophoblast and extraembryonic mesoderm-of 60 first-trimester spontaneous abortions from which cells had failed to grow in culture.
View Article and Find Full Text PDF