Publications by authors named "Natalia N Nukolova"
Purpose: Topical administration is the preferred route of drug delivery for ophthalmic ailments. However, poor permeation through ocular surface and significant systemic absorption, makes the topical drug delivery challenging. Furthermore, distribution of topically delivered drugs varies with their physicochemical properties and the type of formulation used.
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- * Researchers designed nanogels that carry the chemotherapy drug cisplatin, which are linked to antibodies targeting proteins Cx43 and BSAT1, leading to significant tumor reduction in animal models.
- * The study showed that these targeted nanogels not only reduced tumor size but also extended survival rates in treated rats, highlighting a promising new approach for glioma treatment.