Bayesian Clinical Trials.

The following is an introduction from the guest editors for the Bayesian Clinical Trials series.

Why are not There More Bayesian Clinical Trials? Perceived Barriers and Educational Preferences Among Medical Researchers Involved in Drug Development.

Objective And Background: The clinical trials community has been hesitant to adopt Bayesian statistical methods, which are often more flexible and efficient with more naturally interpretable results than frequentist methods. We aimed to identify self-reported barriers to implementing Bayesian methods and preferences for becoming comfortable with them.

Methods: We developed a 22-question survey submitted to medical researchers (non-statisticians) from industry, academia, and regulatory agencies.

Improving economic evaluations in stroke: A report from the ESO Health Economics Working Group.

Introduction: Approaches to economic evaluations of stroke therapies are varied and inconsistently described. An objective of the European Stroke Organisation (ESO) Health Economics Working Group is to standardise and improve the economic evaluations of interventions for stroke.

Methods: The ESO Health Economics Working Group and additional experts were contacted to develop a protocol and a guidance document for data collection for economic evaluations of stroke therapies.