Copper-Catalyzed Synthesis of Pyrrolo[1,2-]quinazolines and Pyrrolo[2,1-]isoquinolines and Antiplasmodial Evaluation.

Reactions involving C(sp)-H bonds of azaarenes have been widely studied in recent years as they allow direct functionalization of these -heterocycles without the use of harsh reaction conditions. In this work, we describe the C(sp)-H functionalization of 4-methylquinazolines and 1-benzylisoquinolines, employing α-substituted β-nitrostyrenes catalyzed by inexpensive copper acetate. Under the optimized condition, 21 pyrrolo[1,2-]quinazolines, as well as an imidazo[1,2-]quinazoline and 4 pyrrolo[2,1-]isoquinolines, were obtained in moderate to good yields.

Asymmetric organocatalyzed synthesis of coumarin derivatives.

Coumarin derivatives are essential scaffolds in medicinal and synthetic chemistry. Compounds of this class have shown important activities, such as anticancer and antiparasitic, besides the commercially available drugs. These properties led to the development of efficient and greener synthetic methods to achieve the 2-chromen-2-one core.

Benzoxazoles as novel herbicidal agents.

Background: Despite the need to develop new herbicides with different modes of action, due to weed resistance, many important classes of compounds have been studied poorly for this purpose. Benzoxazoles are considered privileged structures because of their biological activities, but their phytotoxic activities have not received a lot of attention until now.

Results: Double vinylic substitution reactions were carried out to furnish four 2-nitromethylbenzoxazoles and one oxazolidine.

Peril in the market-classification and dosage of species used as anti-diabetics in Lima, Peru.

Background: Peru is what Peruvian anthropologist Lupe Camino calls the “health axis” of the old Central Andean culture area stretching from Ecuador to Bolivia. In particular in the North of the country the traditional use of medicinal dates back as far as the first millennium B.C.

Evaluation of peritoneal adhesions formation and tissue response to polypropylene - poli (2-hydroxyethyl methacrylate)-(polyHEMA) implant on rats' abdominal wall.

Purpose: To verify if the composit poli (2-hydroxyethyl methacrylate)-PolyHEMA/polypropylene mesh implanted in the female rat's abdominal wall could be suitable for the prevention of peritoneal adhesions, and for the evaluation of the tecidual response produced by this biomaterial.

Methods: Polypropylene meshes (Group PP, n=20) and polypropylene meshes coated with a layer of poli (2-hydroxyethyl methacrylate)-PolyHEMA (Group PH, n=20) were implanted on the abdominal wall of Wistar female rats. Ten animals from each group were submitted to euthanasia at 15 and 30 days of the postoperative period.