Publications by authors named "Natalia Lukianova"
Background: Prostate cancer (PCa) is common malignancy among men worldwide. To date only few molecular markers are available to predict its course and outcome. SPARC is considered to be promising prognostic marker of PCa due to its involvement in various cancer processes.
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- The study examines the challenges faced by first-year university students, focusing on gender differences in academic motivation, coping strategies, and burnout in a cross-cultural context, involving Italian and Russian students.
- A total of 1,133 students participated, with assessments conducted using established scales for academic motivation, coping strategies, and burnout to gather relevant data.
- Results indicate significant gender and cultural differences in academic experiences, suggesting practical applications for academic career guidance to help improve student outcomes and reduce dropout rates.
Does insulin make breast cancer cells resistant to doxorubicin toxicity?
Naunyn Schmiedebergs Arch Pharmacol
November 2023
The effects of insulin on the doxorubicin (Dox) sensitivity of breast cancer cell line MCF-7 and its Dox-resistant counterpart MCF-7/Dox were studied and glucose metabolism, content of essential minerals, and the expression of several microRNAs in these cells upon exposure to insulin and Dox were compared. Cell viability colorimetric assay, colorimetric enzymatic technique, flow cytometry, immunocytochemical techniques, inductively-coupled plasma atomic emission spectroscopy, and quantitative polymerase chain reaction were used in the study. We found that insulin in high concentration significantly suppressed Dox toxicity, especially in parental MCF-7 cell line.
View Article and Find Full Text PDFWe aimed to investigate the relationship between the degree of mast cells' (MCs) infiltration and clinicopathological features of prostate cancer (PCa) malignancy and to find out the possible mechanisms of the involvement of these cells in the formation of the aggressive course of the PCa development. The study was conducted on the clinical material of 60 patients with PCa of stages II-III. MCs in the PCa tissue were determined by a histochemical method using toluidine blue.
View Article and Find Full Text PDFWe report on an improved method of synthesis of N-benzylaminoferrocene-based prodrugs and demonstrate its applicability by preparing nine new aminoferrocenes. Their effect on the viability of selected cancer cells having different p53 status was studied. The obtained data are in agreement with the hypothesis that the toxicity of aminoferrocenes is not dependent upon p53 status.
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