Publications by authors named "Natalia Lorman-Carbo"
Article Synopsis
- * Researchers tested these drugs on various breast cancer cell lines and patient tumor samples, evaluating their impact on cell proliferation, key protein levels, and gene expression over different time frames and doses.
- * Findings indicate that both drugs effectively reduce cancer cell growth and alter gene signatures, but their effects on the HER2-enriched signature may vary according to dosage and additional treatments like fulvestrant, highlighting the need for continued research.
Article Synopsis
- Early-stage triple-negative breast cancer (TNBC) has variability in its clinical and biological characteristics, with immune infiltration impacting prognosis, and there’s a need for better genomic tools for treatment decisions.
- This study analyzed genomic and clinical data across seven patient cohorts to evaluate the role of a B-cell/immunoglobulin signature (IGG) in predicting event-free survival (EFS) and overall survival (OS) in TNBC patients.
- Results indicated that IGG is associated with improved EFS and OS, and its integration with tumor staging can help identify patients who may benefit from tailored treatments.
