(-)-α-Bisabolol as a protective agent against epithelial renal cytotoxicity induced by amphotericin B.

Introduction: Amphotericin B (AmB), used for systemic fungal infections, has a limited clinical application because of its high nephrotoxicity. Natural antioxidant and anti-inflammatory substances have been widely studied for protection against drug-induced nephrotoxicity. α-Bisabolol (BIS) has demonstrated a nephroprotective effect on both in vitro and in vivo models.

Antiproliferative activity on (Y strain) of the triterpene 3β,6β,16β-trihidroxilup-20 (29)-ene isolated from .

Chagas disease infects approximately seven million people worldwide. Benznidazole is effective only in the acute phase of the disease, with an average cure rate of 80% between acute and recent cases. Therefore, there is an urgent need to find new bioactive substances that can be effective against parasites without causing so many complications to the host.