Publications by authors named "Natalia Kirsten"

Article Synopsis
  • This study analyzed routine care data for biologic therapy adjustments in psoriasis management from 29 centers in Germany, focusing on patients aged 18-65 with moderate-to-severe plaque psoriasis.
  • Out of 982 patients, 24.4% (240) experienced 297 treatment adjustments, with the average time to the first adjustment being about 8.4 months.
  • The most common reason for adjustments was insufficient effectiveness of the skin treatment, indicating that flexible dosing regimens could enhance management strategies.
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Article Synopsis
  • The S2k guideline for hidradenitis suppurativa/acne inversa (HS/AI) serves as a decision aid for selecting effective treatments for this chronic skin condition, which is characterized by painful lesions in areas rich in apocrine glands.
  • The condition shows a prevalence of 0.3% in Germany, often diagnosed with a significant delay of about 10 years, and can severely impact a patient's quality of life due to the painful and recurrent nature of the disease.
  • Treatment options include various medications like oral tetracyclines and biologics such as adalimumab, with a focus on assessing disease severity using tools like the International Hidradenitis Supp
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Background: In recent years, legal and infrastructural conditions have been set to improve the adoption of digital applications in health care in Germany. The impact of these actions was amplified by the COVID-19 pandemic. So far, no studies have confirmed this progress in dermatology.

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Digital health interventions (DHI) potentially improve the efficiency and effectiveness of dermatological care. Currently, an overview clustering and characterizing the evidence on DHIs is missing. This systematic mapping of the literature aims to analyse published research on DHIs in dermatology to identify trends and gaps in research.

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Introduction: Evaluation of patient-reported outcomes including health-related quality of life (HRQoL) and perceived benefits from treatment has become a fundamental component of medical decision-making. Standardized evaluation of treatment benefits in rosacea based on patient preferences is still lacking.

Objective: Development and validation of an instrument for recording patient-defined benefits in rosacea therapy based on the Patient Benefit Index (PBI) methodology.

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Article Synopsis
  • * A study analyzed 94 patients who switched from ADAO to ABP 501, and found that 33.3% experienced adverse events (AEs) or loss of response (LoR) within 12 to 14 weeks after the switch.
  • * The findings suggest that switching from ADAO to ABP 501 significantly impacts treatment effectiveness, indicating that such switches should be carefully considered, especially for patients maintaining remission.
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Hidradenitis suppurativa is a chronic disease that disrupts patients' physical and psychological well-being. A disease-specific measure was developed and validated for assessing health-related quality of life in hidradenitis suppurativa. After qualitative item development, the quality of life in hidradenitis suppurativa instrument was tested in 101 patients, applying convergent measures and a usability questionnaire.

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Background: Large variations in the quality of psoriasis care lead to patients being willing to bypass the nearest physician to receive higher quality of care. However, it remains unknown whether actual travel time is associated with quality of care. This study aimed to identify perceived quality of care determinants for travel time to the physician among patients with psoriasis in Germany.

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Objectives: Fumaric acid esters (FAEs) are a well-established treatment option for long-term therapy of moderate to severe plaque psoriasis. This study examines effectiveness of FAEs for the treatment of plaque psoriasis in real-world practice at 12 months and if patient characteristics affect the odds of clinical response.

Methods: A descriptive, multivariable logistic regression analysis was conducted in a cohort drawn from the German registry PsoBest.

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Background: Rosacea is a common chronic skin condition, but data on its epidemiology and related comorbidities are scarce.

Objectives: To analyze the prevalence and associated cutaneous comorbidities of rosacea in Germany.

Methods: Voluntary dermatological full-body examinations were conducted between 2001 and 2016 in more than 500 German companies by experienced dermatologists and documented electronically.

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In psoriasis treatment, there is a high need to define meaningful endpoints and differences from the patient perspective to analyze patient-relevant differences of frequently used outcome methods for psoriasis under real-world conditions. A sample of 3116 patients from the German Psoriasis-Registry PsoBest was analyzed for clinical as well as patient-reported outcomes (PRO) after 3- and 6-month treatment. The parameters PASI, DLQI, and PBI were intercorrelated and related to two anchoring variables: (1) patient satisfaction with treatment and (2) perceived complete clearance.

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Introduction: Data on the prevalence of chronic venous disorders (CVD) at the national level in Germany are scarce.

Methods: We performed a population-based observational study based on clinical examinations, personal history, and technical examinations. Data were collected from 2006 to 2015.

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Purpose: Although acne vulgaris (AV) is a common disease and can persist into adulthood, there are few large-scale epidemiological studies on the prevalence of acne vulgaris in adults. The aim of our study was to characterise the epidemiology and comorbidity of acne vulgaris in working adults in Germany.

Patients And Methods: Within the framework of a cross-sectional study, a total of 161,269 employees underwent dermatological whole-body examinations in more than 500 German companies between 2001 and 2016.

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Background: Scabies is one of the most common and, in terms of burden of disease, one of the most significant skin diseases worldwide. In Germany, an increase in cases is currently being discussed, for which reliable data have been lacking until now.

Objectives: The goal is to clarify the prevalence and treatment of scabies in Germany.

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Background: Seborrhea is a skin condition characterized by abundant production of sebum associated with typical dermatological conditions such as rosacea and acne. Little is known about the prevalence of seborrhea and the frequency of concurrent skin diseases in the general population.

Objective: To investigate the epidemiology and comorbidity of seborrhea in the adolescent and adult working population.

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Psoriatic arthritis is a frequent manifestation of psoriasis, and has a high level of impact on physical func-tioning, work ability and quality of life. However, there have been few studies of the epidemiology, development of and risk factors for concomitant psoriatic arthritis in patients with psoriasis. This study analysed data from a German public health insurance database of > 2 million individuals.

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Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that is often associated with comorbidities and quality of life losses. The implementation of evidence-based preventive measures strengthens patient participation and offers the potential to improve quality of care for AD.

Objectives: To assess adherence to guideline-oriented preventive measures in adult patients with AD in dermatological routine care in Germany.

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Background: Most epidemiological data on vitiligo refer to selected environments or focus on the prevalence of comorbidity unrelated to the population.

Objective: Aim of the study was to gain robust representative prevalence data on vitiligo and on associated dermatologic comorbidity in the German adult population.

Methods: A dual population-based approach was applied with 1) primary data obtained between 2004 and 2014 from dermatological exams in the general working population; 2) claims data from a large German statutory health insurance, reference year 2010.

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Background: Large-scale data on the association between psoriasis and atopic diseases are scarce.

Objectives: To evaluate the concomitant prevalence of atopic conditions and psoriasis.

Materials & Methods: In this cross-sectional study, employees between 16 and 70 years of age were examined in more than 400 German companies by dermatologists, between 2006 and 2014.

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Background: Electronic health records (EHRs) offer various advantages for healthcare delivery, especially for chronic and complex diseases such as psoriasis. However, both patients' and physicians' acceptability is required for EHRs to unfold their full potential. Therefore, this study compares patients' and physicians' attitudes towards using EHRs in routine psoriasis care.

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