Background: Hydrogels, containing a large amount of water and exhibiting high biocompatibility, can improve the rheological properties of formulations and adhere well to the application site. In Poland, only 1 hydrogel substrate is currently approved for pharmaceutical compounding: Celugel, based on hydroxyethyl cellulose (HEC).
Objectives: The aim of this study was to investigate how the variation in the raw material composition of Celugel-based hydrogels affects their osmotic pressure values and selected rheological properties.