Genome sequencing reveals molecular subgroups in oral epithelial dysplasia.

This study aimed to analyze the molecular characteristics of oral epithelial dysplasia (OED), highlighting the pathways and variants of genes that are frequently mutated in oral squamous cell carcinoma (OSCC) and other cancers. Ten archival OED cases were retrieved for retrospective clinicopathological analysis and exome sequencing. Comparative genomic analysis was performed between high-grade dysplasia (HGD) and low-grade dysplasia (LGD), focusing on 57 well-known cancer genes, of which 10 were previously described as the most mutated in OSCC.

Community Participation in the Development and Validation of a School Violence Observation Instrument.

Background: School violence is a worldwide public health issue with negative effects on education. Official statistics and reports do not include daily occurrences of violent behavior that may precede severe incidents.

Objectives: This project aimed to engage school community members in the development, validation, and implementation of an observation instrument to identify characteristics of school violence in two Puerto Rican schools.