Publications by authors named "Natalia I Olovnikova"
In this article, we commemorate the life and scientific journey of the brilliant gerontologist-theorist Alexey Olovnikov (1936-2022). In 1971, he published his famous "marginotomy" hypothesis, in which he predicted the replicative shortening of telomeres and its role as a counter of cell divisions and biological age of an organism. This work put forth several remarkable assumptions, including the existence of telomerase, which were confirmed two decades later.
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- Anti-D immunoglobulin (Anti-D Ig) is crucial for preventing hemolytic disease in newborns, and monoclonal IgG anti-Ds (mAb-Ds) show promise for unlimited supply but vary in effectiveness.
- Research analyzed the glycosylation features of various mAb-Ds and found that differences, particularly in fucosylation, significantly impacted their ability to clear red blood cells and prevent immune responses compared to traditional anti-D Ig.
- The study suggests that mAb-Ds with high galactosylation and low fucosylation may enhance red cell clearance at lower doses, leading to effective and cost-efficient prophylaxis.
We have shown previously that hematopoiesis in mice reconstituted with retrovirally marked hematopoietic stem cells (HSCs) is provided by multiple, mainly short-lived clones, as measured by retroviral insertion site analysis of individual spleen colony-forming unit (CFU-S)-derived colonies. However, the CFU-S is the relatively early progenitor and the contribution of each CFU-S in the steady-state hematopoiesis is uncertain. Here, we have studied the fate of individual mature B cells, as well as CFU-S, representing the progeny of retrovirally transduced marrow-repopulating cells (MRC).
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