Naphthoquinones inhibit formation and viability of Yersinia enterocolitica biofilm.

The capacity of different naphthoquinones to inhibit and eradicate Yersinia enterocolitica biofilm was investigated and possible mechanisms of action were evaluated. Inhibition of biofilm formation and cell viability, quorum sensing (QS) inhibition and oxidative stress generation of 23 naphthoquinones were assayed against Yersinia enterocolitica. The best anti-biofilm agents at 100 µmol l were compounds 3, 11 and 13, which showed biofilm inhibition higher than 75%.